Testosterone Replacement Therapy has been shown to be a very safe and effective treatment for men who have been diagnosed with andropause. Once started, the medication should begin to reverse the signs and symptoms of andropause relatively quickly. However, just as andropause tends to have a slow and subtle onset, to the point where you may not even notice it’s happening until it’s a full blown problem, the reversal of andropause with TRT will also be slow and subtle.